Author: Scott Deeter

High-Quality Recombinant Human Serum Albumin (rHSA), Exbumin™, for Improved Cell Wash Buffer Preparation

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Introduction Cell therapy offers a novel approach to medicine, leveraging the body’s own cellular machinery to treat a variety of indications in regenerative medicine, immune disease, and cancer.1 Since the mid 1990s, scientists have been exploring ways to create robust and reliable manufacturing systems leveraging high-quality, well-defined, GMP (Good Manufacturing Practice)-grade raw materials.2,3 Traditionally sourced …

Process Optimization for Lentivirus Production in the iCELLis® Nano Using a Chemically Defined, Animal Component Free HEK293 Media

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  Abstract Use of FBS in large scale clinical manufacturing applications represents a significant risk due to potential adventitious agent contamination, unreliable supply chain from limited global supply, and considerable variability in vector yield due to lot-to-lot composition variations. To circumvent the many challenges and drawbacks associated with using serum in viral vector production media …

Exbumin – Reconstitution Application Note

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Workflow Summary Weigh Exbumin (lyophilized powder) and determine final total volume of the solution. Add 70% of the final volume of DPBS, PBS, or basal media. Allow the solution to set for 12 hours at 4°C. Adjust the volume to account for volume increase from powder. Sterile filter and store at 2-8°C or freeze at …