OptiVERO^®

Product Description

OptiVERO® is a chemically defined, blood-free cell culture media system, specifically formulated to maximize VERO-based virus production in both 2D and 3D culture formats. Unlike traditional media that rely on plant hydrolysates or serum-derived components, OptiVERO provides a fully defined, scalable, and regulatory-friendly solution for vaccine manufacturing, virology research, and viral vector production.

Designed to reduce cell culture variability and accelerate virus manufacturing timelines, OptiVERO is supplied as a two-component kit consisting of a concentrated frozen protein supplement and a base media, allowing for greater flexibility and precise control over media composition.

Manufactured in an ISO 9001:2015-certified, cGMP-compliant facility in the United States, OptiVERO ensures batch-to-batch consistency, pathogen-free safety, and global regulatory compliance, making it an ideal solution for virology research and commercial vaccine production.

Advantages

• Optimized for VERO Cell-Based Virus Production
  • Engineered for both 2D and 3D VERO cell culture systems, enabling scalable virus manufacturing.
  • Enhances viral yield and production efficiency, improving process consistency for vaccine development.
  • Accelerates research and development timelines, reducing variability in cell growth and virus propagation.
• Fully Chemically Defined & Blood-Free
  • Does not contain undefined plant hydrolysates, ensuring greater consistency in bioprocessing.
  • Blood-free, animal-origin-free formulation, reducing regulatory concerns and improving batch reproducibility.
  • Eliminates reliance on undefined components, providing a more controlled environment for virus growth.
• Two-Component Media System for Greater Control
  • Supplied as a two-component kit, including:
    • Concentrated frozen protein supplement
    • Base media
  • Allows for precise customization and flexibility in media preparation, supporting both small-scale and large-scale bioproduction.
  • Easily integrates into closed-system bioreactors, optimizing viral vector and vaccine development workflows.
• Animal-Origin-Free Assurance
  • 100% chemically defined and animal-origin-free (AOF) – eliminating risks associated with serum-derived media.
  • Manufactured using a non-animal, non-human host system, ensuring purity and reproducibility.
  • Raw materials, manufacturing equipment, and packaging are fully animal-free, aligning with regulatory and ethical standards.
• Manufactured in the United States
  • Produced in a tertiary-level, ISO 9001:2015-certified facility in the USA.
  • Complete supply and manufacturing chain is owned and operated by InVitria, ensuring unmatched traceability and quality control.
  • Batch-to-batch consistency for reliable integration into cGMP virology workflows.

Applications

• Vaccine Manufacturing & Virology Research
  • Optimized for VERO cell-based virus propagation, ensuring high viral titers for vaccine production.
  • Enables chemically defined, reproducible cell culture conditions, critical for regulatory compliance in vaccine development.
• Biopharmaceutical & Viral Vector Production
  • Enhances AAV, lentivirus, and other viral vector production, supporting gene therapy applications.
  • Reduces process variability, ensuring consistent virus yields across production batches.
• 2D & 3D Cell Culture Systems
  • Designed to support both monolayer and suspension-based VERO cell cultures.
  • Scalable for bioreactor-based virus production, ensuring efficient large-scale manufacturing.

Technical Specifications

• Formulation: Two-component system (Concentrated frozen protein supplement + Base media)
• Manufacturing: Produced in a state-of-the-art, ISO 9001:2015-certified facility in the USA
• Quality Assurance:
  • Fully recombinant and animal-origin-free production system
  • Stringent quality control processes ensure high batch-to-batch consistency
• Regulatory Compliance & Safety:
  • cGMP-compliant manufacturing
  • Plasma-free, pathogen-free, and chemically defined
  • Aligned with regulatory expectations for biopharmaceutical and vaccine production applications

Why Choose OptiVERO?

OptiVERO is a high-performance, chemically defined alternative to traditional VERO cell media, offering superior virus yield, batch consistency, and regulatory compliance. Whether used for vaccine development, viral vector production, or virology research, OptiVERO provides a safe, scalable, and animal-free solution for industrial and research applications.

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