Exbumin Provides Improved Performance and Stability in Vaccine Development

Abstract A key aspect of vaccine production is maintaining stability and function of the final product, including sustained potency and viral titer.  Indeed, this knowledge has driven various preservation strategies, such as lyophilization, temperature control, and localized constitution for use.  However, these are only partial solutions; these strategies introduce their own challenges to vaccine stability …

Formulation and Production of Serum-Free OptiVERO Media

Abstract Vaccines provide effective protection against many infectious diseases as well as therapeutics for select pathologies, such as cancer. Many viral vaccines require amplification of virus in cell cultures during manufacture. Traditionally, cell cultures, such as VERO, have been used for virus production in bovine serum‐containing culture media. However, due to concerns of potential adventitious …

Recent Advances of Chemical Definition of Cell Culture Media and Excipients for Virus and Viral Vector Manufacturing

A vital step in the manufacturing of vaccines and viral vector-based cell and gene therapies is virus production. Historically, virus production relies heavily on undefined and highly variable raw material for cell-based platforms to be successful. Yet due to supply chain constraints, poor reproducibility, and safety concerns attributed to potential adventitious agents present in serum …

Poster 2021: Application of Biomass Probe with Chemically Defined Media in iCELLis

Utilization of classical adherent formats in large scale viral vector manufacturing can have significant setbacks due to the lack of scalability of production vessels typically used at small scale. The iCELLis fixed bed bioreactor has emerged as an enabling technology to efficiently scale adherent-based processes in a controlled and highly integrated environment. This technology has …

Emergence of a Blood-Free rHSA

Albumin is a naturally occurring protein in animals and humans responsible for numerous cellular functions and is integral to the manufacturing of biopharmaceuticals. Various benefits of albumin inclusion in upstream manufacturing, downstream processing, and final formulation applications will be discussed in detail but can be briefly summarized as: Serves as an antioxidant and benefitting stability …