Rapid Quantitation of SARS-CoV-2 Antibodies Using an Electrochemical Sensor

Published on 1 April 2026

Rapid detection of antibodies in complex clinical samples requires both sensitivity and control of non-specific interactions.

This study shows how recombinant human albumin supports assay performance in electrochemical biosensor systems.

Publication Details

Publication Title: Rapid quantitation of SARS-CoV-2 antibodies in clinical samples with an electrochemical sensor
Journal: Biosensors and Bioelectronics
Year: 2023
Article Type: Peer-reviewed research
DOI: 10.1016/j.bios.2022.115037

Study Overview

This study describes the development of a multiplexed electrochemical biosensor for rapid detection of SARS-CoV-2 antibodies in clinical samples, including plasma and dried blood spots. The platform enables antibody detection in under 10 minutes using minimal sample volume while maintaining high sensitivity and specificity.

Key Findings

• The electrochemical biosensor demonstrated 100% sensitivity and specificity across clinical samples
• Antibody detection was achieved in <10 minutes using 1.5 µL of sample
• The system supports multiplexed detection and point-of-care applications
• Antifouling surface chemistry reduces non-specific binding and improves assay performance

Why This Matters

• Rapid, sensitive antibody detection is critical for serological surveillance and vaccine response monitoring
• Assay performance in complex samples depends on reducing background noise and non-specific interactions
• Defined, recombinant components improve consistency and reliability in diagnostic systems

Relevant Applications

• Diagnostic assay development
• Biosensors and electrochemical detection systems
• Serological testing and antibody quantitation
• Point-of-care diagnostics
• Clinical sample analysis (plasma, dried blood spots)

Where InVitria Fits

Recombinant human albumin from InVitria (Exbumin®) was used in the biosensor coating and assay system as an alternative to BSA. The study demonstrated comparable performance with reduced background signal in negative samples, supporting the use of recombinant albumin in sensitive diagnostic applications.

Explore Recombinant Human Albumin