Author: Alexia Armstrong

ITS-Animal-Free™ Supplementation for iPSC Expansion and Pluripotency: A Platform Approach for Serum-Free Cell Expansion

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Overview This application note evaluates the use of ITS Animal-Free™ (ITS AF)—a recombinant, animal-origin-free supplement containing insulin, transferrin, and selenium—for serum-free expansion of human induced pluripotent stem cells (iPSCs). The study demonstrates that ITS AF supports robust iPSC proliferation and maintains high levels of Oct4, Sox2, and Nanog expression, performing comparably to a leading competitor …

Safe, Consistent Iron Delivery in Serum-Free Systems with Optiferrin® Recombinant Transferrin

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Overview Efficient iron delivery plays a critical role in maintaining cell health, supporting proliferation, and maximizing therapeutic productivity. However, serum-derived transferrin introduces variability, regulatory risk, and the potential for contamination. This application note demonstrates how Optiferrin, a recombinant transferrin for iron delivery in serum-free media, provides a consistent and animal-origin-free alternative. It mirrors native transferrin …

Why Border Disruptions Threaten Blood-Derived Raw Materials—and What Biomanufacturers Can Do About It

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Reading time: 4 minutes What happens when your biologics pipeline depends on the reliability of an international border? For many manufacturers still using plasma-derived components like albumin or transferrin, that’s not a hypothetical. It’s baked into their supply chain. Across the U.S.–Mexico border, more than 50 plasma centers depend on daily crossings from Mexican nationals …

Low-DMSO Cryopreservation of MSCs with Optibumin 25 Recombinant Albumin

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OverviewThis application note evaluates the use of Optibumin® 25—a recombinant, animal-origin-free human serum albumin—for low-DMSO cryopreservation of umbilical cord-derived mesenchymal stem cells (UC-MSCs). The study demonstrates that Optibumin enables DMSO reduction to as low as 1% while maintaining post-thaw MSC viability and reducing apoptosis, matching or outperforming blood-derived HSA. Key Findings Maintains MSC viability at …

Sustained T Cell Proliferation and Early Memory Retention with OptiLeukin™ 2 Recombinant IL-2

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Key Points InVitria’s OptiLeukin™ 2, a high-purity (≥ 98%), GMP-grade, recombinant human interleukin-2 (IL-2) enables robust expansion of primary T cells. OptiLeukin 2 supports the generation of T cells with a favorable memory phenotype, essential for long-term therapeutic persistence. OptiLeukin 2 matches the performance of leading GMP IL-2 products, enabling a seamless like-kind replacement. OptiLeukin …

InVitria Launches OptiLeukin 2 Recombinant Interleukin-2

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InVitria® Launches OptiLeukin™ 2: A Chemically Defined, Animal- and Bacteria-Free Recombinant IL-2 for Immune Cell Manufacturing Junction City, KS – April 21, 2025 – InVitria®, a leading provider of recombinant, chemically defined biomanufacturing and formulation components, today announced the launch of OptiLeukin™ 2, a high-purity, animal- and bacteria-free recombinant human interleukin-2 (IL-2) designed for immune …