Author: Alexia Armstrong

Improve Diagnostic Immunoassay Performance with Optibumin 25 Recombinant Human Serum Albumin

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EXECUTIVE SUMMARY Sensitive, reliable immunoassays are essential for early disease detection, where false-negative results can delay treatment. Albumin is commonly used in diagnostic immunoassays as a blocking agent and sample diluent, yet not all albumins perform the same. Aggregate populations present in conventional serum-derived albumins can scatter light and contribute to nonspecific background signal, elevating …

rHSA Improves Infectious Lentiviral Titer Yield During Tangential Flow Filtration by Passivating Filter Surfaces

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EXECUTIVE SUMMARY Infectious lentiviral titer is often lost during tangential flow filtration (TFF) in downstream processing due to shear and viral adsorption to filter membranes. Albumin is a known shear protectant and surface passivator that should address these mechanisms of loss. Bandiera et al. previously demonstrated that coating TFF membranes with plasma-derived human serum albumin …

Recombinant Albumin Improves Lentiviral Vector Recovery After Freeze-Thaw Stress

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EXECUTIVE SUMMARY Lentiviral vectors (LVVs) are widely used for gene delivery in cell and gene therapy workflows, but infectious titer can decline during downstream processing, storage, and freeze-thaw handling. Although cryopreservation at -80 °C is commonly used to limit thermal degradation, freeze-thaw stress can reduce LVV recovery through ice formation, osmotic stress, interfacial exposure, adsorption, …

Recombinant Albumin Enhances Lentiviral Vector Stability During Downstream Processing

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Lentiviral vectors (LVVs) remain one of the most widely used gene delivery systems for ex vivo cell therapy manufacturing, including CAR-T workflows, and are increasingly being explored for in vivo gene delivery applications. However, enveloped viral particles are highly sensitive to manufacturing-related stress during downstream processing. Operations such as tangential flow filtration (TFF), sterile filtration, …

Enhanced Cryopreservation of Therapeutically Relevant Cells

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Reduced-DMSO cryopreservation workflows often compromise post-thaw viability, expansion, and functional cell attributes due to increased cellular stress during freeze/thaw. In a comparative study across T cells, mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSCs), InVitria® evaluated whether recombinant human serum albumin (rHSA) could improve cryopreservation performance relative to plasma-derived HSA (pHSA) and albumin-free …

InVitria Presents ASGCT 2026 Data on rHSA for Lentiviral Vector Manufacturing

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FOR IMMEDIATE RELEASE InVitria Presents New Data at ASGCT 2026 on Recombinant Human Serum Albumin for Higher Lentiviral Vector Titers and Improved Cell Therapy Manufacturing JUNCTION CITY, Kan., May 12, 2026 — InVitria, a global leader in chemically defined, animal-origin-free recombinant proteins for advanced therapy manufacturing, announced its participation in the American Society of Gene …