ITSE + A^™ – Blood-free cell culture media supplement

Product Description

ITSE + Albumin Animal-Free™  is a 100x recombinant insulin, transferrin, albumin, selenium, and ethanolamine cell culture supplement, specifically formulated to reduce or fully replace fetal bovine serum (FBS) or human serum in cell culture media. Designed for chemically defined, serum-free applications, this fully recombinant supplement enhances cell growth, metabolic function, and oxidative stress protection, ensuring optimal performance across a range of mammalian cell types, including CHO, HEK, and primary cells.

As a cost-effective and regulatory-friendly alternative to serum, ITSE + Albumin Animal-Free provides the essential nutrients, iron transport, and antioxidant protection required for cell viability and productivity. Manufactured in an ISO 9001:2015-certified, cGMP-compliant facility in the United States, ITSE + Albumin Animal-Free ensures batch-to-batch consistency, pathogen-free safety, and seamless integration into biopharmaceutical, cell therapy, and regenerative medicine applications.

Advantages

• Optimized for Serum-Free, Animal-Origin-Free Cell Culture
  • Fully recombinant, blood-free supplement, eliminating batch variability and contamination risks associated with serum-derived components.
  • Enhances cell proliferation, metabolic activity, and viability in chemically defined media.
  • Designed for FBS replacement, reducing reliance on undefined serum components.
• Essential Components for Cell Growth & Performance
  • Insulin – Stimulates cell signaling, glucose uptake, and amino acid transport, supporting metabolic function.
  • Transferrin – Provides a non-toxic iron carrier, preventing oxidative stress and free-radical formation.
  • Albumin – Stabilizes cell membranes, proteins, and hydrophobic molecules, reducing shear stress in culture.
  • Selenium – Supports antioxidant enzyme activity, protecting cells from oxidative damage.
  • Ethanolamine – A phospholipid precursor, essential for membrane integrity and the growth of select cell types.
• Animal-Origin-Free Assurance
  • 100% chemically defined and animal-origin-free (AOF) – eliminating risks associated with serum-derived components.
  • Manufactured using a non-animal, non-human host system, ensuring purity and reproducibility.
  • Raw materials, manufacturing equipment, and packaging are fully animal-free, aligning with regulatory and ethical standards.
• Manufactured in the United States
  • Produced in a tertiary-level, ISO 9001:2015-certified facility in the USA.
  • Complete supply and manufacturing chain is owned and operated by InVitria, ensuring unmatched traceability and quality control.
  • Batch-to-batch consistency for reliable integration into cGMP cell culture workflows.
• Ready-to-Use 100x Sterile Liquid Format
  • Supplied as a 100x sterile liquid, allowing for precise supplementation in cell culture media.
  • Blood-free components improve performance consistency, ensuring reproducibility across experiments.
  • Cost-effective formulation, providing an alternative to expensive serum-based supplements.

Applications

• Serum-Free & Reduced-Serum Cell Culture
  • Supports CHO, HEK, VERO, and stem cell culture in chemically defined media.
  • Enhances cell viability and proliferation, reducing dependence on FBS or human serum.
• Cell Therapy & Regenerative Medicine
  • Provides a chemically defined alternative to serum-derived insulin, transferrin, and albumin.
  • Ensures greater control over cell culture conditions for stem cell and immune cell expansion.
• Biopharmaceutical & Vaccine Production
  • Improves cell productivity in protein and viral vector production workflows.
  • Enhances growth and metabolic stability in CHO and HEK-based biomanufacturing.

Technical Specifications

• Formulation: 100x sterile liquid cell culture supplement
• Manufacturing: Produced in a state-of-the-art, ISO 9001:2015-certified facility in the USA
• Quality Assurance:
  • Fully recombinant and animal-origin-free production system
  • Stringent quality control processes ensure high batch-to-batch consistency
• Regulatory Compliance & Safety:
  • cGMP-compliant manufacturing
  • Plasma-free, pathogen-free, and chemically defined
  • Aligned with regulatory expectations for biopharmaceutical, regenerative medicine, and vaccine production applications

Why Choose ITSE + Albumin Animal-Free?

ITSE + Albumin Animal-Free is a cost-effective, chemically defined alternative to traditional serum-based supplements, offering unparalleled purity, stability, and regulatory compliance. Whether used for serum-free biomanufacturing, cell therapy, or regenerative medicine, ITSE + Albumin AF provides a safe, scalable, and animal-free solution for industrial and research applications.

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