EXECUTIVE SUMMARY Lentivirus production is central to CAR-T manufacturing, and is even more critical with the emergence of in vivo CAR-T approaches. This puts increased emphasis on the need for high-yield lentivirus manufacturing. However, lentiviruses are inherently fragile, and infectious titer is lost at every step in manufacturing. The shift towards suspension systems, and chemically …
Reading time: 4 minutes Share this article: For decades, the biopharmaceutical industry has relied on Pluronic F68 (Poloxamer 188, P188) as the standard shear protectant in sparged bioreactors. This reliance emerged from regulatory pressure to remove serum-derived contaminants, including BSE and TSE from manufacturing workflows. More recently, however, manufacturing disruptions linked to poloxamer 188, have …
InVitria has entered a strategic collaboration with Cellevate AB to explore improved upstream solutions for viral vaccine production. The collaboration brings together Cellevate’s Cellevat3d® nanofiber microcarrier platform with InVitria’s chemically defined recombinant proteins to support scalable, animal-origin-free vaccine manufacturing workflows. Cellevat3d enables high-density adherent cell culture, while InVitria’s recombinant media components help provide consistent and …
This poster evaluates recombinant human serum albumin (rHSA, Optibumin® 25) as a structurally defined alternative to plasma-derived human serum albumin (pHSA) in T cell wash and cryopreservation workflows. Analytical characterization (SEC and Cys34 redox) demonstrates reduced aggregate burden and structural heterogeneity, with functional validation in T cell and MSC cryopreservation, including reduced-DMSO conditions. Equivalent T …
The InVitria 2026 Product Catalog provides a comprehensive overview of recombinant, animal-origin-free proteins and chemically defined solutions designed for modern biomanufacturing. These products support a wide range of applications including cell and gene therapy manufacturing, biologics production, vaccine development, regenerative medicine, and diagnostics. Inside the catalog, you will find detailed information on InVitria’s portfolio of …
Reading time: 4 minutes Share this article: Polysorbate 20 and polysorbate 80 have long been treated as default stabilizers in biopharmaceutical formulations. They are effective surfactants and, for many years, have been viewed as a practical solution to interfacial stress and aggregation. Over time, however, a growing body of evidence has shown that these excipients …
