How tightening regulations and new data are reshaping expectations for material consistency and traceability. Ask anyone in advanced therapy manufacturing “What keeps you up at night?”…the answer is usually the same; variability. Every batch tells a story, some of success, some of struggle. Manufacturers work hard to control what they can, the process itself. Yet …
Webinar Details Title: Why Cell Quality Erodes During Downstream Processing — and How to Prevent It Date & Time: ON DEMAND Host: GEN (Genetic Engineering & Biotechnology News) Sponsored by: InVitria What You’ll Learn Key factors contributing to cell quality loss during purification, washing, and formulation steps How raw material selection impacts viability, phenotype, and …
Download the poster to see how OptiVERO supports consistent, scalable virus production without serum or plant hydrolysates. Learn how this optimized formulation enables robust VERO cell expansion in both 2D and 3D culture, maintains healthy morphology, and delivers equivalent or higher viral yields for Dengue, Zika, and influenza compared to FBS and VP-SFM.
Overview Human serum albumin (HSA) plays a vital role in drug complexation and delivery. However, plasma-derived HSA is heterogeneous due to donor variation, stabilizers, and aggregates that can interfere with drug binding. These inconsistencies can affect pharmacokinetics, reduce formulation predictability, and complicate regulatory alignment. In this application note, InVitria compares Optibumin® 25, an animal-origin-free recombinant …
Download the poster to see how Optibumin® 25 and PentaHibe® support safer CAR-T manufacturing with low-DMSO, animal-origin-free cryopreservation that improves T cell viability, expansion, and functionality.
Overview Covalent conjugation of drugs and diagnostic reagents to albumin is a widely used strategy in drug development. This approach improves solubility, stability, and pharmacokinetics while offering high specificity through the free thiol group at cysteine-34 (Cys34). However, plasma-derived human serum albumin (HSA) is a deficient and inconsistent conjugation partner — up to 40% of …
Overview This application note evaluates the performance of Optibumin® 25, a recombinant, animal-origin-free human serum albumin (rHSA), in the cryopreservation of human induced pluripotent stem cells (iPSCs). The study demonstrates that Optibumin 25 enables a significant reduction in DMSO concentration while improving post-thaw viability, expansion, and pluripotency. Compared to blood-derived HSA, Optibumin 25 delivers superior …
Overview This application note presents a defined, animal-origin-free (AOF) cryopreservation strategy addressing the limitations of high-DMSO and serum-derived components. The formulation—10% PentaHibe Base, 2% DMSO, and 4% Optibumin 25—was tested in CAR-T–mimicking workflows using healthy donor T cells. PentaHibe Base is a non-penetrating, carbohydrate-based cryoprotectant derived from pentaisomaltose, a patented subfraction of Dextran 1 with …
Download the Optibumin 20 Guidelines for Use to learn preparation, concentrations, storage, and applications of recombinant HSA. High free‑thiol Cys‑34 content and 99% fatty‑acid‑free profile support small‑molecule solubilization, bioconjugation, and sensitive applications including iPSC, hESC, and IVF.
Download the Lacromin® Guidelines for Use to learn preparation, concentrations, storage, and applications of recombinant human lactoferrin. This animal-origin-free supplement supports CHO, HEK, pluripotent, and select primary cell cultures.
