Author: Alexia Armstrong
InVitria Launches Optibumin 25 rHSA
InVitria® Introduces Optibumin® 25: The First 25% Animal-Free Recombinant Human Serum Albumin for Cell & Gene Therapy Manufacturing Junction City, KS – February 20, 2025 – InVitria, a leading provider of recombinant, chemically defined biomanufacturing and formulation components, today announced the launch of Optibumin 25, the first and only recombinant human serum albumin (rHSA) available …
Cryopreservation Just Got Better with Optibumin® 25
Reading time: 6 minutes Share this article: Optimizing Cryopreservation with Animal-Origin-Free HSA Solutions Struggling with cell viability after thawing? You’re not alone. Cryopreservation plays a crucial role in biomanufacturing, especially in developing cell-based therapies, where post-thaw viability can impact everything from functionality to clinical success. Traditionally, dimethyl sulfoxide (DMSO) has been the go-to cryoprotectant, …
Retain and Protect Final Cell Product with Optibumin®, a Recombinant Human Serum Albumin (rHSA)
Key Points Optibumin®, InVitria’s high-purity recombinant human albumin, improves viable T cell retention during downstream washing. Optibumin performs comparably to clinical serum-derived HSA in this application, enabling a like-kind replacement. Optibumin is animal origin free, offering safety and regulatory advantages. Introduction Critical Role of Albumin in Cell Washing for Cell Therapy Cell washing occurs at …
How Regulatory Bodies Are Driving the Shift to Animal-Origin-Free Solutions in Cell Therapy and Vaccine Development
Reading time: 6 minutes Share this article: Global regulatory agencies—including the FDA (U.S. Food and Drug Administration), EMA (European Medicines Agency), WHO (World Health Organization), and PMDA (Pharmaceuticals and Medical Devices Agency of Japan)—are driving the shift to animal-origin-free (AOF) solutions in cell therapy and vaccine manufacturing. Their goal: to enhance product safety, standardize …
Enhanced Cryopreservation of T Cells Using Optibumin®, Recombinant Human Serum Albumin (rHSA)
Key Points Optibumin® Improves T Cell Recovery and Proliferation Post-Thaw Optibumin significantly enhances T cell viability and proliferation post-thaw compared to human blood-derived clinical HSA. Reduction of DMSO Concentrations in CryoStor® Formulations The inclusion of Optibumin solution physically displaces an equal volume of CryoStor to enable a reduction in final DMSO concentrations, improving the safety …
Advancing Vaccine Excellence
InVitria is transforming vaccine production with safer, scalable, and sustainable solutions. This infographic showcases how our recombinant, animal-free technologies address key challenges in traditional vaccine manufacturing, such as contamination risks, inconsistent supply, and cold chain logistics. Key highlights include: Safer Solutions: Eliminate risks from animal- and human-derived components, ensuring vaccine quality and patient safety. Scalable …
Innovative Solutions in Closed-System Biomanufacturing: Exploring the Tools and Technologies Driving Sterility and Efficiency
Reading time: 4 minutes Share this article: As biomanufacturers strive to meet the growing demand for high-purity therapeutics, closed-system biomanufacturing has emerged as a cornerstone for success. In our previous post, we explored the evolving challenges in implementing closed systems, from maintaining sterility to navigating regulatory requirements. Now, we turn our focus to the …
Evolving Challenges in Closed-System Biomanufacturing
Reading time: 5 minutes Share this article: Closed-system biomanufacturing has revolutionized cell and gene therapy production, offering unparalleled sterility and control. However, as the industry advances and regulatory expectations for contamination control increase, new challenges arise that demand innovative solutions. In this blog post, we’ll explore the evolving complexities of closed systems and …
T Cell Cryopreservation Using Exbumin®, Recombinant Human Serum Albumin, and Reduced DMSO
Key Points Exbumin®, recombinant human serum albumin (rHSA), demonstrated superior T cell viability, health, and proliferation post-cryopreservation compared to clinical HSA and a 10% DMSO solution. Notably, this was achieved with only 2.5% DMSO, demonstrating Exbumin’s ability to reduce DMSO concentrations without compromising cell health. Exbumin is an approved excipient for therapeutic injection and offers …