Author: Alexia Armstrong

Recombinant Albumin as a Carrier Protein Improves Cytokine Recovery and Functional Stability at Dilute Concentrations

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    Audio Summary: Optibumin 25 Stabilizes High-Cost Cytokines EXECUTIVE SUMMARY High-value cytokines and growth factors are the economic and functional drivers of modern cell therapy and biomanufacturing, frequently accounting for over 80% of total media costs. However, these critical investments are constantly at risk due to inherent protein fragility, leading to rapid aggregation, surface …

Variability and Failed Lots: The Hidden Quality Control Challenge of Serum & Serum-Derived Products

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Reading time: 4 minutes Share this article:   The biopharmaceutical industry faces a critical quality control challenge: the inherent variability of serum and plasma-derived products. While traditionally relied upon for cell culture, blood-derived albumin introduces significant lot-to-lot inconsistencies in protein heterogeneity, growth factor content, and biochemical profiles. These variations directly impact manufacturing success, particularly in …

Consistency Is the New Compliance

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How tightening regulations and new data are reshaping expectations for material consistency and traceability. Ask anyone in advanced therapy manufacturing “What keeps you up at night?”…the answer is usually the same; variability. Every batch tells a story, some of success, some of struggle. Manufacturers work hard to control what they can, the process itself. Yet …

Why Cell Quality Erodes During Downstream Processing — and How to Prevent It | Webinar

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Webinar Details Title: Why Cell Quality Erodes During Downstream Processing — and How to Prevent It Date & Time: ON DEMAND Host: GEN (Genetic Engineering & Biotechnology News) Sponsored by: InVitria What You’ll Learn Key factors contributing to cell quality loss during purification, washing, and formulation steps How raw material selection impacts viability, phenotype, and …

A Binding Advantage: Optibumin 25 Demonstrates Enhanced Drug Binding and Consistency over Plasma Albumin

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EXECUTIVE SUMMARY Human serum albumin (HSA) is exemplary among proteins in drug complexation applications. It is capable of binding a wide variety of ligands with high affinity, is resistant to renal filtration, has a lengthy in vivo half-life, is incredibly soluble, and contains multiple drug binding sites. These unique pharmacological properties of albumin are due …

Thiol by Combat: Enhanced Covalent Conjugation with Recombinant Albumin Compared to Human Plasma-Derived Albumin

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EXECUTIVE SUMMARY Covalent conjugation of drugs and diagnostic imaging reagents to albumin is a versatile and widely used strategy in pharmacology. This chemistry improves drug stability in serum, reduces renal clearance, and increases solubility, while also being highly specific. Conjugation is usually accomplished by reacting a pharmacological agent with the free thiol form of albumin’s …

Improved iPSC Cryopreservation with Optibumin 25: Enhanced Viability, Expansion, and Pluripotency

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Audio Summary: Improved iPSC Cryopreservation with Optibumin 25 EXECUTIVE SUMMARY Optibumin 25, InVitria’s recombinant animal-origin-free human serum albumin, improves post-thaw viability, expansion, and maintenance of pluripotency in iPSCs when used in cryopreservation formulations. Compared to plasma-derived HSA, Optibumin 25 demonstrated significantly greater improvements in cell health and survival. Additionally, supplementing CryoStor® CS5 with 5% Optibumin …

Superior Cryopreservation of T Cells in Low-DMSO, Animal-Origin-Free Formulation Using Optibumin 25 and PentaHibe Base

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EXECUTIVE SUMMARY This application note presents a defined, animal-origin-free (AOF) cryopreservation strategy addressing the limitations of high-DMSO and serum-derived components. The formulation—10% PentaHibe Base, 2% DMSO, and 4% Optibumin 25—was tested in CAR-T–mimicking workflows using healthy donor T cells. PentaHibe Base is a non-penetrating, carbohydrate-based cryoprotectant derived from pentaisomaltose, a patented subfraction of Dextran 1 …